Drosophila expressing human SOD1 successfully recapitulates mitochondrial phenotypic features of familial Amyotrophic Lateral Sclerosis

• Main Authors: Gallart-Palau, Xavier, Ng, Chee-Hoe, Ribera, Joan, Sze, Siu Kwan, Lim, Kah-Leong
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: FALS; SOD1G93A
• Online Access: https://hdl.handle.net/10356/84611; http://hdl.handle.net/10220/41891
• Institution: Nanyang Technological University

Mitochondrial pathology is a seminal pathogenic hallmark of familial amyotrophic lateral sclerosis (FALS) which is extensively manifested by human patients and mutant SOD1G93A mammalian models. Rodents expressing human FALS-associated mutations successfully mimic several human disease features; alth...