Investigation of Functional Group Effects on Palladium Catalysed Asymmetric P–H Addition

Investigation of Functional Group Effects on Palladium Catalysed Asymmetric P–H Addition

The pincer catalysed asymmetric P–H addition of diphenylphosphine to 3-benzylidene-2,4-pentadione is herein reported. Albeit successful in catalysing a series of similar substrates, unexpected chelation of the dione substrate to a CP and CN palladacycle catalyst resulted in inactivation of the catal...

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Bibliographic Details
Main Authors: Li, Xi-Rui, Chew, Renta Jonathan, Li, Yongxin, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2016
Subjects:
Catalysts
Phosphorus compounds
Online Access:https://hdl.handle.net/10356/84714
http://hdl.handle.net/10220/41919
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Institution: Nanyang Technological University
Language: English
Description
Summary:The pincer catalysed asymmetric P–H addition of diphenylphosphine to 3-benzylidene-2,4-pentadione is herein reported. Albeit successful in catalysing a series of similar substrates, unexpected chelation of the dione substrate to a CP and CN palladacycle catalyst resulted in inactivation of the catalyst with adjacent coordination sites. Protected phosphine adducts were isolated and characterised, providing critical insights to the choice of catalyst for structurally distinct functional groups borne by the substrate.

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