Branched Peptide, B2088, Disrupts the Supramolecular Organization of Lipopolysaccharides and Sensitizes the Gram-negative Bacteria

• Main Authors: Lakshminarayanan, Rajamani, Tan, Wei Xiang, Aung, Thet Tun, Goh, Eunice Tze Leng, Muruganantham, Nandhakumar, Li, Jianguo, Chang, Jamie Ya Ting, Dikshit, Neha, Saraswathi, Padmanabhan, Lim, Rayne Rui, Kang, Tse Siang, Balamuralidhar, Vanniarajan, Sukumaran, Bindu, Verma, Chandra S., Sivaraman, Jayaraman, Chaurasia, Shyam Sunder, Liu, Shouping, Beuerman, Roger W.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Antibiotics; Bacterial infection
• Online Access: https://hdl.handle.net/10356/84726; http://hdl.handle.net/10220/41946
• Institution: Nanyang Technological University

Dissecting the complexities of branched peptide-lipopolysaccharides (LPS) interactions provide rationale for the development of non-cytotoxic antibiotic adjuvants. Using various biophysical methods, we show that the branched peptide, B2088, binds to lipid A and disrupts the supramolecular organizati...