Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa

• Main Authors: Fong, July, Yuan, Mingjun, Jakobsen, Tim Holm, Mortensen, Kim T., Delos Santos, May Margarette Salido, Chua, Song Lin, Yang, Liang, Tan, Choon Hong, Givskov, Michael, Nielsen, Thomas Eiland
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Disulfide Bond; Ajoene Analogues
• Online Access: https://hdl.handle.net/10356/85223; http://hdl.handle.net/10220/43675
• Institution: Nanyang Technological University

Since its discovery 22 years ago, the bacterial cell-to-cell communication system, termed quorum sensing (QS), has shown potential as antipathogenic target. Previous studies reported that ajoene from garlic inhibits QS in opportunistic human pathogen Pseudomonas aeruginosa. In this study, screening...