A loss-of-function study of CRTC1 in hippocampal neurons at basal state and during long-term synaptic plasticity

• Main Author: Lim, Agnes Fang Yi
• Other Authors: Ch’ng Toh Hean
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/85237; http://hdl.handle.net/10220/49191
• Institution: Nanyang Technological University

Encoding of long-term memory in neurons requires gene expression and protein synthesis. CREB, a well-characterised stimulus-induced transcription factor, is implicated in gene transcription supporting long-term plasticity. Several studies showed that CRTC1 is an important co-activator for CREB ac...