Electron microscopy and biochemical analysis of native telomeric chromatin

• المؤلف الرئيسي: Ahsan, Bilal
• مؤلفون آخرون: Sara Sandin
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2019
• الموضوعات: Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/85247; http://hdl.handle.net/10220/49204
• المؤسسة: Nanyang Technological University

Human telomeres are G-rich sequence repeats of DNA that span the terminal ends of chromosomes with an average length of about 10,000 base pairs. Telomeric DNA acts as a platform for the recruitment of a six protein-complex called shelterin. The shelterin complex protects chromosome ends from fusion...