Collective cell migration on artificial extracellular matrix proteins containing full-length fibronectin domains
The discovery of the cell-adhesive properties of the Arg-Gly-Asp (RGD) sequence located in the tenth type III domain of fi bronectin triggered widespread use of RGD-functionalized materials for directing cell behavior. [ 1,2 ] In studies of cell adhesion and migration, however, cell responses on...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/85262 http://hdl.handle.net/10220/6946 |
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| Institution: | Nanyang Technological University |
| Language: | English |
| Summary: | The discovery of the cell-adhesive properties of the Arg-Gly-Asp
(RGD) sequence located in the tenth type III domain of
fi bronectin triggered widespread use of RGD-functionalized
materials for directing cell behavior. [ 1,2 ] In studies of cell adhesion
and migration, however, cell responses on RGD surfaces
are never identical to those observed on fi bronectin. [ 3 ] For
example, we recently examined the attachment and patterning
of Rat-1 fi broblasts on elastin-based artifi cial extracellular matrix
(aECM) proteins bearing a fi bronectin-derived RGD sequence
and found the average projected area of such cells to be approximately
60% of those spread on fi bronectin. |
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