Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sen...
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Nanyang Technological University
2019
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sg-ntu-dr.10356-853002023-02-28T23:45:05Z Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism Xu, Yuan Liu Xuewei School of Physical and Mathematical Sciences XueWei@ntu.edu.sg DRNTU::Science::Physics To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sense, we have successfully synthesized degradable glycosylated antibacterial polycaprolactones. Besides, a series of ROMP polymers with acid and base sensitivity have been produced and preliminary results suggested that the scaffold is possible to be applied as antimicrobial agents. Aside from this, an alternative strategy to construct molecules targeting both Gram-positive and Gram-negative cell walls has been developed. Doctor of Philosophy 2019-05-15T08:16:41Z 2019-12-06T16:01:06Z 2019-05-15T08:16:41Z 2019-12-06T16:01:06Z 2019 Thesis-Doctor of Philosophy Xu, Y. (2019). Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/85300 http://hdl.handle.net/10220/48211 10.32657/10220/48211 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). 191 p. application/pdf Nanyang Technological University |
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DRNTU::Science::Physics Xu, Yuan Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
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To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sense, we have successfully synthesized degradable glycosylated antibacterial polycaprolactones. Besides, a series of ROMP polymers with acid and base sensitivity have been produced and preliminary results suggested that the scaffold is possible to be applied as antimicrobial agents. Aside from this, an alternative strategy to construct molecules targeting both Gram-positive and Gram-negative cell walls has been developed. |
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Liu Xuewei |
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Liu Xuewei Xu, Yuan |
format |
Thesis-Doctor of Philosophy |
author |
Xu, Yuan |
author_sort |
Xu, Yuan |
title |
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
title_short |
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
title_full |
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
title_fullStr |
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
title_full_unstemmed |
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
title_sort |
design and synthesis of (glyco) polymers and peptidoglycan complex with new bacterial killing mechanism |
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Nanyang Technological University |
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2019 |
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https://hdl.handle.net/10356/85300 http://hdl.handle.net/10220/48211 |
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1759855460094050304 |