Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism

To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sen...

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Main Author: Xu, Yuan
Other Authors: Liu Xuewei
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2019
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Online Access:https://hdl.handle.net/10356/85300
http://hdl.handle.net/10220/48211
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Institution: Nanyang Technological University
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spelling sg-ntu-dr.10356-853002023-02-28T23:45:05Z Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism Xu, Yuan Liu Xuewei School of Physical and Mathematical Sciences XueWei@ntu.edu.sg DRNTU::Science::Physics To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sense, we have successfully synthesized degradable glycosylated antibacterial polycaprolactones. Besides, a series of ROMP polymers with acid and base sensitivity have been produced and preliminary results suggested that the scaffold is possible to be applied as antimicrobial agents. Aside from this, an alternative strategy to construct molecules targeting both Gram-positive and Gram-negative cell walls has been developed. Doctor of Philosophy 2019-05-15T08:16:41Z 2019-12-06T16:01:06Z 2019-05-15T08:16:41Z 2019-12-06T16:01:06Z 2019 Thesis-Doctor of Philosophy Xu, Y. (2019). Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/85300 http://hdl.handle.net/10220/48211 10.32657/10220/48211 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). 191 p. application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Science::Physics
spellingShingle DRNTU::Science::Physics
Xu, Yuan
Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
description To combat drug resistant bacteria, synthetic antimicrobial polymeric materials have attracted considerable attention in recent years. However, most synthetic antimicrobial polymers are consisting of non-degradable carbon-based backbones, limiting their potential in clinical applications. In this sense, we have successfully synthesized degradable glycosylated antibacterial polycaprolactones. Besides, a series of ROMP polymers with acid and base sensitivity have been produced and preliminary results suggested that the scaffold is possible to be applied as antimicrobial agents. Aside from this, an alternative strategy to construct molecules targeting both Gram-positive and Gram-negative cell walls has been developed.
author2 Liu Xuewei
author_facet Liu Xuewei
Xu, Yuan
format Thesis-Doctor of Philosophy
author Xu, Yuan
author_sort Xu, Yuan
title Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
title_short Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
title_full Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
title_fullStr Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
title_full_unstemmed Design and synthesis of (Glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
title_sort design and synthesis of (glyco) polymers and peptidoglycan complex with new bacterial killing mechanism
publisher Nanyang Technological University
publishDate 2019
url https://hdl.handle.net/10356/85300
http://hdl.handle.net/10220/48211
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