Dengue virus-infected dendritic cells, but not monocytes, activate natural killer cells through a contact-dependent mechanism involving adhesion molecules

Dengue virus-infected dendritic cells, but not monocytes, activate natural killer cells through a contact-dependent mechanism involving adhesion molecules

Natural killer (NK) cells play a protective role against dengue virus (DENV) infection, but the cellular and molecular mechanisms are not fully understood. Using an optimized humanized mouse model, we show that human NK cells, through the secretion of gamma interferon (IFN-γ), are critical in the ea...

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Bibliographic Details
Main Authors: Costa, Vivian Vasconcelos, Ye, Weijian, Chen, Qingfeng, Teixeira, Mauro Martins, Preiser, Peter, Ooi, Eng Eong, Chen, Jianzhu
Other Authors: Palese, Peter
Format: Article
Language:English
Published: 2019
Subjects:
Dengue Virus
Adhesion Molecule
Science::Biological sciences
Online Access:https://hdl.handle.net/10356/85405
http://hdl.handle.net/10220/50195
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/85405
http://hdl.handle.net/10220/50195

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