Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1/2 mutations in a Southeast Asian country

• Main Authors: Chew, Winston, Moorakonda, Rajesh Babu, Courtney, Eliza, Soh, Hazel, Li, Shao Tzu, Chen, Yanni, Shaw, Tarryn, Allen, John Carson, Evans, Dafydd Gareth R., Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Medicine; BRCA 1; HER2 Receptor
• Online Access: https://hdl.handle.net/10356/85532; http://hdl.handle.net/10220/49224
• Institution: Nanyang Technological University

Background : Germline mutations in the BRCA1 and BRCA2 genes have significant clinical implications for both risk-reducing and early surveillance management. The third and most recent revision of the Manchester scoring system (MSS3) used to distinguish patients indicated for germline BRCA1/2 testing...