Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease

• Main Authors: Mohammad Zarei, Barroso, Emma, Palomer, Xavier, Dai, Jianli, Rada, Patricia, Quesada-López, Tania, Escolà-Gil, Joan Carles, Cedó, Lidia, Mohammad Reza Zali, Molaei, Mahsa, Dabiri, Reza, Vázquez, Santiago, Pujol, Eugènia, Valverde, Ángela M., Villarroya, Francesc, Liu, Yong, Wahli, Walter, Vázquez-Carrera, Manuel
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: VLDLR; PPAR
• Online Access: https://hdl.handle.net/10356/85541; http://hdl.handle.net/10220/45208
• Institution: Nanyang Technological University

Objective: The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)β/δ and fibroblast growth factor 21 (FGF21) in hepatic VLDLR regulation. Methods:...