Proapoptotic cyclic peptide BC71 targets cell-surface GRP78 and functions as an anticancer therapeutic in mice

• Main Authors: Kao, Chieh, Chandna, Ritu, Ghode, Abhijeet, Dsouza, Charlotte, Chen, Mo, Larsson, Andreas, Lim, Siau Hoi, Wang, Minjun, Cao, Zhonglian, Zhu, Yizhun, Anand, Ganesh S., Ge, Ruowen
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Isthmin (ISM); Glucose Regulated Protein 78 kDa (GRP78)
• Online Access: https://hdl.handle.net/10356/85552; http://hdl.handle.net/10220/45182
• Institution: Nanyang Technological University

Glucose regulated protein 78 kDa (GRP78) is a recently emerged target for cancer therapy and a biomarker for cancer prognosis. Overexpression of GRP78 is observed in many types of cancers, with the cell-surface GRP78 being preferentially present in cancer cells and cancer blood vessel endothelial ce...