Live-cell imaging and functional dissection of Xist RNA reveal mechanisms of X chromosome inactivation and reactivation

Live-cell imaging and functional dissection of Xist RNA reveal mechanisms of X chromosome inactivation and reactivation

We double-tagged Xist (inactivated X chromosome-specific transcript), a prototype long non-coding RNA pivotal for X chromosome inactivation (XCI), using the programmable RNA sequence binding domain of Pumilio protein, one tag for live-cell imaging and the other replacing A-repeat (a critical domain...

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Bibliographic Details
Main Authors: Ha, Norbert How Ong, Lai, Lan-Tian, Chelliah, Rosi, Zhen, Yashu, Seet, Vanessa Pei Yi, Lai, Soak-Kuan, Li, Hoi-Yeung, Ludwig, Alexander, Sandin, Sara, Chen, Lingyi, Zhang, Li-Feng
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2019
Subjects:
Science::Biological sciences::Molecular biology
Genetics
Cell Biology
Online Access:https://hdl.handle.net/10356/85701
http://hdl.handle.net/10220/49844
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/85701
http://hdl.handle.net/10220/49844

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