Composite mathematical modeling of calcium signaling behind neuronal cell death in Alzheimer’s disease

• Main Authors: Ranjan, Bobby, Chong, Ket Hing, Zheng, Jie
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Calcium Signaling; Neuronal Cell Death
• Online Access: https://hdl.handle.net/10356/86094; http://hdl.handle.net/10220/45259
• Institution: Nanyang Technological University

Background: Alzheimer’s disease (AD) is a progressive neurological disorder, recognized as the most common cause of dementia affecting people aged 65 and above. AD is characterized by an increase in amyloid metabolism, and by the misfolding and deposition of β-amyloid oligomers in and around neurons...