Palladium-catalyzed enantioselective arylation of racemic ketones to form bridged bicycles via dynamic kinetic resolution

• المؤلفون الرئيسيون: Huang, Xiaolei, Oh, William Ray Jun Jie, Zhou, Steve Jianrong
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Alkylation; DRNTU::Science::Chemistry; Palladium Catalysis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86101; http://hdl.handle.net/10220/48295

Enantioselective α‐arylation of racemic ketones containing existing α′‐stereocenters is reported for the first time via base‐induced dynamic kinetic resolution. Bridged bicyclic rings are formed in good ee values, which are difficult to obtain otherwise. Furthermore, reactions in DMSO‐d6 resulted in...