Palladium-catalyzed enantioselective arylation of racemic ketones to form bridged bicycles via dynamic kinetic resolution

• Main Authors: Huang, Xiaolei, Oh, William Ray Jun Jie, Zhou, Steve Jianrong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Alkylation; DRNTU::Science::Chemistry; Palladium Catalysis
• Online Access: https://hdl.handle.net/10356/86101; http://hdl.handle.net/10220/48295
• Institution: Nanyang Technological University

Enantioselective α‐arylation of racemic ketones containing existing α′‐stereocenters is reported for the first time via base‐induced dynamic kinetic resolution. Bridged bicyclic rings are formed in good ee values, which are difficult to obtain otherwise. Furthermore, reactions in DMSO‐d6 resulted in...