Detection of proteoglycan loss from articular cartilage using Brillouin microscopy, with applications to osteoarthritis

• Main Authors: Wu, Pei-Jung, Masouleh, Maryam Imani, Dini, Daniele, Paterson, Carl, Török, Peter, Overby, Darryl R., Kabakova, Irina V.
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Elastic Scattering; Brillouin Microscopy; Science::Physics
• Online Access: https://hdl.handle.net/10356/86181; http://hdl.handle.net/10220/49855
• Institution: Nanyang Technological University

The degeneration of articular cartilage (AC) occurs in osteoarthritis (OA), which is a leading cause of pain and disability in middle-aged and older people. The early disease-related changes in cartilage extra-cellular matrix (ECM) start with depletion of proteoglycan (PG), leading to an increase in...