Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo

• المؤلفون الرئيسيون: Lim, Chun Hwee, Puthia, Manoj, Butrym, Marta, Tay, Hui Min, Lee, Michelle Zi Yi, Hou, Han Wei, Schmidtchen, Artur
• مؤلفون آخرون: Interdisciplinary Graduate School (IGS)
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Neutrophils; Sepsis
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86509; http://hdl.handle.net/10220/44087
• المؤسسة: Nanyang Technological University

Host defence peptides (HDPs) derived from the C-terminus of thrombin are proteolytically generated by enzymes released during inflammation and wounding. In this work, we studied the effects of the prototypic peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), on neutrophil functions. In vitro, GKY25 was show...