Long-Term Culture of Self-renewing Pancreatic Progenitors Derived from Human Pluripotent Stem Cells

• Main Authors: Trott, Jamie, Tan, Ee Kim, Ong, Sheena, Titmarsh, Drew M., Denil, Simon L.I.J., Giam, Maybelline, Wong, Cheng Kit, Wang, Jiaxu, Shboul, Mohammad, Eio, Michelle, Cooper-White, Justin, Cool, Simon M., Rancati, Giulia, Stanton, Lawrence W., Reversade, Bruno, Dunn, Norris Ray
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Culture Conditions; Pancreatic Progenitors
• Online Access: https://hdl.handle.net/10356/86521; http://hdl.handle.net/10220/44039
• Institution: Nanyang Technological University

Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent...