Guanidine-catalyzed asymmetric Strecker reaction: modes of activation and origin of stereoselectivity

• Main Authors: Xue, Hansong, Tan, Choon-Hong, Wong, Ming Wah
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Organocatalysis; Strecker Reaction
• Online Access: https://hdl.handle.net/10356/86553; http://hdl.handle.net/10220/44066
• Institution: Nanyang Technological University

Density functional theory calculations were employed to study the catalytic mechanism, modes of activation, and origin of enantioselectivity of guanidine-catalyzed asymmetric Strecker reaction of N-benzhydryl imine with hydrogen cyanide. Two types of bifunctional activation mode were identified, nam...