Guanidine-catalyzed asymmetric Strecker reaction: modes of activation and origin of stereoselectivity

• المؤلفون الرئيسيون: Xue, Hansong, Tan, Choon-Hong, Wong, Ming Wah
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2017
• الموضوعات: Organocatalysis; Strecker Reaction
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/86553; http://hdl.handle.net/10220/44066

Density functional theory calculations were employed to study the catalytic mechanism, modes of activation, and origin of enantioselectivity of guanidine-catalyzed asymmetric Strecker reaction of N-benzhydryl imine with hydrogen cyanide. Two types of bifunctional activation mode were identified, nam...