Long range recognition and selection in IDPs : the interactions of the C-terminus of p53

• Main Authors: Kannan, Srinivasaraghavan, Lane, David P., Verma, Chandra Shekhar
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Protein Binding; Intrinsically Disordered Proteins; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/86585; http://hdl.handle.net/10220/46690
• Institution: Nanyang Technological University

The C-terminal domain of p53 is an extensively studied IDP, interacting with different partners through multiple distinct conformations. To explore the interplay between preformed structural elements and intrinsic fluctuations in its folding and binding we combine extensive atomistic equilibrium and...