A broad range quorum sensing inhibitor working through sRNA inhibition

• Main Authors: Stegger, Marc, Lorenzen, Frederik, Rybtke, Morten, Moscoso, Joana A., Jakobsen, Tim H., Warming, Anders N., Vejborg, Rebecca M., Andersen, Jens B., Petersen, Rico, Andersen, Paal Skytt, Nielsen, Thomas Eiland, Tolker-Nielsen, Tim, Filloux, Alain, Ingmer, Hanne, Givskov, Michael
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Microbiology; Pathogenesis
• Online Access: https://hdl.handle.net/10356/86614; http://hdl.handle.net/10220/44156
• Institution: Nanyang Technological University

For the last decade, chemical control of bacterial virulence has received considerable attention. Ajoene, a sulfur-rich molecule from garlic has been shown to reduce expression of key quorum sensing regulated virulence factors in the opportunistic pathogen Pseudomonas aeruginosa. Here we show that t...