A ferritin-containing nanoconjugate as MRI image-guidance to target Necl-5, a tumor-surface antigen: a potential thermal accelerant for microwave ablation

• Main Authors: Park, William K. C., Mills, David R., Lim, Sierin, Sana, Barindra, Frank, Victoria E., Kenyon, Brendan M., Primmer, Michael P., Paul, Jarod B., Baird, Greyson L., Walsh, Edward G., Dupuy, Damian E.
• Other Authors: Ryan, Thomas P.
• Format: Conference or Workshop Item
• Language: English
• Published: 2018
• Subjects: Ferritin; Nanoconjugate
• Online Access: https://hdl.handle.net/10356/86825; http://hdl.handle.net/10220/44303
• Institution: Nanyang Technological University

Purpose: A ferritin-containing nanoparticle conjugated with a target-specific antibody was investigated as a MRI contrast agent for tumor detection. A genetically modified ferritin to markedly improve Fe (III) payload (up to 7,000 Fe ions), was chemically tethered to a monoclonal antibody against ra...