Rapid access to bicyclic δ-lactones via carbene-catalyzed activation and cascade reaction of unsaturated carboxylic esters

• Main Authors: Fu, Zhenqian, Wu, Xingxing, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Iridoid; Bicyclic Ring
• Online Access: https://hdl.handle.net/10356/87048; http://hdl.handle.net/10220/45223
• Institution: Nanyang Technological University

Carboxylic esters are an excellent choice of substrates in organic synthesis. Here we demonstrate that carbene-catalyzed activation of α,β-unsaturated ester can be developed to synthesize sophisticated multi-cyclic molecules in a single step cascade process. The iridoid-type lactone products are obt...