Crystallographic and enzymatic insights into the mechanisms of Mg-ADP inhibition in the A1 complex of the A1AO ATP synthase

• Main Authors: Singh, Dhirendra, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: A1AO ATP Synthase; Methanosarcina Mazei Gö1
• Online Access: https://hdl.handle.net/10356/87069; http://hdl.handle.net/10220/44273
• Institution: Nanyang Technological University

F-ATP synthases are described to have mechanisms which regulate the unnecessary depletion of ATP pool during an energy limited state of the cell. Mg-ADP inhibition is one of the regulatory features where Mg-ADP gets entrapped in the catalytic site, preventing the binding of ATP and further inhibitin...