Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis

• Main Authors: Boopathy, Gandhi T. K., Kulkarni, Madhura, Ho, Sze Yuan, Chua, Edmond Wei Min, Boey, Adrian, Barathi, Veluchamy A., Carney, Tom J., Wang, Xiaomeng, Hong, Wanjin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Angiogenesis; Cell Biology
• Online Access: https://hdl.handle.net/10356/87202; http://hdl.handle.net/10220/44347
• Institution: Nanyang Technological University

Angiogenesis is a highly regulated process for formation of new blood vessels from pre-existing ones. Angiogenesis is dysregulated in various pathologies, including age-related macular degeneration, arthritis, and cancer. Inhibiting pathological angiogenesis therefore represents a promising therapeu...