ANGPTL4 T266M variant is associated with reduced cancer invasiveness

• Main Authors: Tan, Zhen Wei, Teo, Ziqiang, Tan, Carol, Choo, Chee Chong, Loo, Wei Sheng, Song, Yiyang, Tam, Zhi Yang, Ng, Sean Pin, Koh, Hong Zheng, Ng, Yi Siang, Shochat, Susana Geifman, Yau, Yin Hoe, Zhu, Pengcheng, Tan, Nguan Soon
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: ANGPTL4; Anoikis resistance
• Online Access: https://hdl.handle.net/10356/87230; http://hdl.handle.net/10220/44354
• Institution: Nanyang Technological University

Angiopoietin-like 4 (ANGPTL4) is a secretory protein that can be cleaved to form an N-terminal and a C-terminal protein. Studies performed thus far have linked ANGPTL4 to several cancer-related and metabolic processes. Notably, several point mutations in the C-terminal ANGPTL4 (cANGPTL4) have been r...