Pseudomonas Aeruginosa Oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis

• Main Authors: Chen, Fei, Chen, Gukui, Liu, Yiwei, Jin, Yongxin, Cheng, Zhihui, Liu, Yang, Yang, Liang, Jin, Shouguang, Wu, Weihui
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Oligoribonuclease; Pyocin
• Online Access: https://hdl.handle.net/10356/87238; http://hdl.handle.net/10220/45353
• Institution: Nanyang Technological University

Bacterial oligoribonuclease (Orn) is a conserved 3′-to-5′ exonuclease. In Pseudomonas aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG, which is required for cyclic-di-GMP homeostasis. Meanwhile, Orn is involved in the degradation of nanoRNAs, which can alte...