Pseudomonas Aeruginosa Oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis

• Main Authors: Chen, Fei, Chen, Gukui, Liu, Yiwei, Jin, Yongxin, Cheng, Zhihui, Liu, Yang, Yang, Liang, Jin, Shouguang, Wu, Weihui
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Oligoribonuclease; Pyocin
• 在線閱讀: https://hdl.handle.net/10356/87238; http://hdl.handle.net/10220/45353
• 機構: Nanyang Technological University

Bacterial oligoribonuclease (Orn) is a conserved 3′-to-5′ exonuclease. In Pseudomonas aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG, which is required for cyclic-di-GMP homeostasis. Meanwhile, Orn is involved in the degradation of nanoRNAs, which can alte...