Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution

• Main Authors: Chung, Hwa Hwa, Or, Yu Zuan, Shrestha, Smeeta, Loh, Jia Tong, Lim, Chew Leng, Ong, Zoe, Woo, Amanda Rui En, Su, I-hsin, Lin, Valerie Chun Ling
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Estrogen; Mammary Involution
• Online Access: https://hdl.handle.net/10356/87345; http://hdl.handle.net/10220/44423
• Institution: Nanyang Technological University

Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Mic...