Toll-Like Receptor 4, but Not Neutrophil Extracellular Traps, Promote IFN Type I Expression to Enhance Th2 Responses to Nippostrongylus brasiliensis

• Main Authors: Pellefigues, Christophe, Tang, Shiau-Choot, Schmidt, Alfonso, White, Ruby F., Lamiable, Olivier, Connor, Lisa M., Ruedl, Christiane, Dobrucki, Jurek, Le Gros, Graham, Ronchese, Franca
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Helminth; Nippostrongylus Brasiliensis
• Online Access: https://hdl.handle.net/10356/87377; http://hdl.handle.net/10220/44458
• Institution: Nanyang Technological University

The induction of Th2 responses is thought to be multifactorial, and emerge from specific pathways distinct from those associated with antagonistic antibacterial or antiviral Th1 responses. Here, we show that the recognition of non-viable Nippostrongylus brasiliensis (Nb) in the skin induces a strong...