Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis

Pyruvate kinase (PYK) is an essential glycolytic enzyme that controls glycolytic flux and is critical for ATP production in all organisms, with tight regulation by multiple metabolites. Yet the allosteric mechanisms governing PYK activity in bacterial pathogens are poorly understood. Here we report...

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Main Authors: Zhong, Wenhe, Cui, Liang, Goh, Boon Chong, Cai, Qixu, Ho, Peiying, Chionh, Yok Hian, Yuan, Meng, Sahili, Abbas El, Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Lescar, Julien, Dedon, Peter Christian
其他作者: School of Biological Sciences
格式: Article
語言:English
出版: 2018
主題:
Mycobacterium Tuberculosis
Mycobacterium Bovis BCG
在線閱讀:https://hdl.handle.net/10356/87429
http://hdl.handle.net/10220/44406
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https://hdl.handle.net/10356/87429
http://hdl.handle.net/10220/44406

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