Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes

Objective: Rates of diabetes mellitus are higher in South Asians than in other populations and persist after migration. One unexplored cause may be higher exposure to persistent organic pollutants associated with diabetes in other populations. We compared organochlorine (OC) pesticide concentrations...

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Main Authors: Elliott, Paul, Kooner, Jaspal, Macherone, Anthony, McMullin, Matthew, Zhang, Luoping, Chambers, John Campbell, Sanchez, Sylvia S., La Merrill, Michele A., Hubbard, Alan E., Smith, Martyn T., Daniels, Sarah I.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
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Online Access:https://hdl.handle.net/10356/87452
http://hdl.handle.net/10220/49883
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-874522020-11-01T05:20:57Z Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes Elliott, Paul Kooner, Jaspal Macherone, Anthony McMullin, Matthew Zhang, Luoping Chambers, John Campbell Sanchez, Sylvia S. La Merrill, Michele A. Hubbard, Alan E. Smith, Martyn T. Daniels, Sarah I. Lee Kong Chian School of Medicine (LKCMedicine) Dichlorodiphenyldichloroethylene Dichlorodiphenyltrichloroethane Science::Medicine Objective: Rates of diabetes mellitus are higher in South Asians than in other populations and persist after migration. One unexplored cause may be higher exposure to persistent organic pollutants associated with diabetes in other populations. We compared organochlorine (OC) pesticide concentrations in South Asian immigrants and European whites to determine whether the disease was positively associated with OC pesticides in South Asians. Research Design and Methods: South Asians of Tamil or Telugu descent (n = 120) and European whites (n = 72) were recruited into the London Life Sciences Population Study cohort. Blood samples as well as biometric, clinical, and survey data were collected. Plasma levels of p,p′-dichlorodiphenyldichloroethylene (DDE), p,p′- dichlorodiphenyltrichloroethane, β-hexachlorohexane (HCH), and polychlorinated biphenyl-118 were analyzed by gas chromatography-mass spectrometry. South Asian cases and controls were categorized by binary exposure (above vs below the 50th percentile) to perform logistic regression. Results: Tamils had approximately threefold to ninefold higher levels of OC pesticides, and Telugus had ninefold to 30-fold higher levels compared with European whites. The odds of exposure to p,p′-DDE above the 50th percentile was significantly greater in South Asian diabetes cases than in controls (OR: 7.00; 95% CI: 2.22, 22.06). The odds of exposure to β-HCH above the 50th percentile was significantly greater in the Tamil cases than in controls (OR: 9.35; 95% CI: 2.43, 35.97). Conclusions: South Asian immigrants have a higher body burden of OC pesticides than European whites. Diabetes mellitus is associated with higher p,p′-DDE and β-HCH concentrations in this population. Additional longitudinal studies of South Asian populations should be performed. NMRC (Natl Medical Research Council, S’pore) MOH (Min. of Health, S’pore) Published version 2019-09-05T05:38:27Z 2019-12-06T16:42:12Z 2019-09-05T05:38:27Z 2019-12-06T16:42:12Z 2018 Journal Article Daniels, S. I., Chambers, J. C., Sanchez, S. S., La Merrill, M. A., Hubbard, A. E., Macherone, A., . . . Kooner, J. (2018). Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes. Journal of the Endocrine Society, 2(8), 832-841. doi:10.1210/js.2017-00480 https://hdl.handle.net/10356/87452 http://hdl.handle.net/10220/49883 10.1210/js.2017-00480 en Journal of the Endocrine Society © 2019 Endocrine Society. This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). 10 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Dichlorodiphenyldichloroethylene
Dichlorodiphenyltrichloroethane
Science::Medicine
spellingShingle Dichlorodiphenyldichloroethylene
Dichlorodiphenyltrichloroethane
Science::Medicine
Elliott, Paul
Kooner, Jaspal
Macherone, Anthony
McMullin, Matthew
Zhang, Luoping
Chambers, John Campbell
Sanchez, Sylvia S.
La Merrill, Michele A.
Hubbard, Alan E.
Smith, Martyn T.
Daniels, Sarah I.
Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
description Objective: Rates of diabetes mellitus are higher in South Asians than in other populations and persist after migration. One unexplored cause may be higher exposure to persistent organic pollutants associated with diabetes in other populations. We compared organochlorine (OC) pesticide concentrations in South Asian immigrants and European whites to determine whether the disease was positively associated with OC pesticides in South Asians. Research Design and Methods: South Asians of Tamil or Telugu descent (n = 120) and European whites (n = 72) were recruited into the London Life Sciences Population Study cohort. Blood samples as well as biometric, clinical, and survey data were collected. Plasma levels of p,p′-dichlorodiphenyldichloroethylene (DDE), p,p′- dichlorodiphenyltrichloroethane, β-hexachlorohexane (HCH), and polychlorinated biphenyl-118 were analyzed by gas chromatography-mass spectrometry. South Asian cases and controls were categorized by binary exposure (above vs below the 50th percentile) to perform logistic regression. Results: Tamils had approximately threefold to ninefold higher levels of OC pesticides, and Telugus had ninefold to 30-fold higher levels compared with European whites. The odds of exposure to p,p′-DDE above the 50th percentile was significantly greater in South Asian diabetes cases than in controls (OR: 7.00; 95% CI: 2.22, 22.06). The odds of exposure to β-HCH above the 50th percentile was significantly greater in the Tamil cases than in controls (OR: 9.35; 95% CI: 2.43, 35.97). Conclusions: South Asian immigrants have a higher body burden of OC pesticides than European whites. Diabetes mellitus is associated with higher p,p′-DDE and β-HCH concentrations in this population. Additional longitudinal studies of South Asian populations should be performed.
author2 Lee Kong Chian School of Medicine (LKCMedicine)
author_facet Lee Kong Chian School of Medicine (LKCMedicine)
Elliott, Paul
Kooner, Jaspal
Macherone, Anthony
McMullin, Matthew
Zhang, Luoping
Chambers, John Campbell
Sanchez, Sylvia S.
La Merrill, Michele A.
Hubbard, Alan E.
Smith, Martyn T.
Daniels, Sarah I.
format Article
author Elliott, Paul
Kooner, Jaspal
Macherone, Anthony
McMullin, Matthew
Zhang, Luoping
Chambers, John Campbell
Sanchez, Sylvia S.
La Merrill, Michele A.
Hubbard, Alan E.
Smith, Martyn T.
Daniels, Sarah I.
author_sort Elliott, Paul
title Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
title_short Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
title_full Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
title_fullStr Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
title_full_unstemmed Elevated levels of organochlorine pesticides in South Asian immigrants are associated with an increased risk of diabetes
title_sort elevated levels of organochlorine pesticides in south asian immigrants are associated with an increased risk of diabetes
publishDate 2019
url https://hdl.handle.net/10356/87452
http://hdl.handle.net/10220/49883
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