EZH2 promotes neoplastic transformation through VAV interaction-dependent extranuclear mechanisms

• Main Authors: Venkatesan, Nandini, Wong, Jong Fu, Tan, Kuan Pern, Chung, Hwa Hwa, Yau, Yin Hoe, Cukuroglu, Engin, Allahverdi, Abdollah, Nordenskiold, Lars, Goke, Jonathan, Geifman-Shochat, Susana, Lin, Valerie Chun Ling, Madhusudhan, M. S., Su, I-hsin
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: EZH2; VAV
• Online Access: https://hdl.handle.net/10356/87507; http://hdl.handle.net/10220/44455; https://doi.org/10.21979/N9/AJYMP5
• Institution: Nanyang Technological University

Recently, we reported that the histone methyltransferase, EZH2, controls leukocyte migration through interaction with the cytoskeleton remodeling effector, VAV, and direct methylation of the cytoskeletal regulatory protein, Talin. However, it is unclear whether this extranuclear, epigenetic-independ...