Nonstructural proteins of alphavirus—potential targets for drug development

Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the A...

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Main Authors: Abu Bakar, Farhana, Ng, Lisa F. P.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2018
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Online Access:https://hdl.handle.net/10356/87583
http://hdl.handle.net/10220/45435
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-875832023-02-28T17:02:04Z Nonstructural proteins of alphavirus—potential targets for drug development Abu Bakar, Farhana Ng, Lisa F. P. School of Biological Sciences Alphavirus Replication Nonstructural Protein Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o’nyong’nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination. We also summarize recent structural data of these viral targets and discuss how these could serve as templates to facilitate structure-based drug design and development of small molecule inhibitors. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2018-08-02T06:31:32Z 2019-12-06T16:45:00Z 2018-08-02T06:31:32Z 2019-12-06T16:45:00Z 2018 Journal Article Abu Bakar, F., & Ng, L. F. P. (2018). Nonstructural proteins of alphavirus—potential targets for drug development. Viruses, 10(2), 71-. 1999-4915 https://hdl.handle.net/10356/87583 http://hdl.handle.net/10220/45435 10.3390/v10020071 en Viruses © 2018 The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 15 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Alphavirus Replication
Nonstructural Protein
spellingShingle Alphavirus Replication
Nonstructural Protein
Abu Bakar, Farhana
Ng, Lisa F. P.
Nonstructural proteins of alphavirus—potential targets for drug development
description Alphaviruses are enveloped, positive single-stranded RNA viruses, typically transmitted by arthropods. They often cause arthralgia or encephalitic diseases in infected humans and there is currently no targeted antiviral treatment available. The re-emergence of alphaviruses in Asia, Europe, and the Americas over the last decade, including chikungunya and o’nyong’nyong viruses, have intensified the search for selective inhibitors. In this review, we highlight key molecular determinants within the alphavirus replication complex that have been identified as viral targets, focusing on their structure and functionality in viral dissemination. We also summarize recent structural data of these viral targets and discuss how these could serve as templates to facilitate structure-based drug design and development of small molecule inhibitors.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Abu Bakar, Farhana
Ng, Lisa F. P.
format Article
author Abu Bakar, Farhana
Ng, Lisa F. P.
author_sort Abu Bakar, Farhana
title Nonstructural proteins of alphavirus—potential targets for drug development
title_short Nonstructural proteins of alphavirus—potential targets for drug development
title_full Nonstructural proteins of alphavirus—potential targets for drug development
title_fullStr Nonstructural proteins of alphavirus—potential targets for drug development
title_full_unstemmed Nonstructural proteins of alphavirus—potential targets for drug development
title_sort nonstructural proteins of alphavirus—potential targets for drug development
publishDate 2018
url https://hdl.handle.net/10356/87583
http://hdl.handle.net/10220/45435
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