Calcineurin B in CD4+ T cells prevents autoimmune colitis by negatively regulating the JAK/STAT pathway

• Main Authors: Mencarelli, Andrea, Vacca, Maurizio, Khameneh, Hanif Javanmard, Acerbi, Enzo, Tay, Alicia, Zolezzi, Francesca, Poidinger, Michael, Mortellaro, Alessandra
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Calcineurin B; Nuclear Factor of Activated T Cell
• Online Access: https://hdl.handle.net/10356/87680; http://hdl.handle.net/10220/45534
• Institution: Nanyang Technological University

Calcineurin (Cn) is a protein phosphatase that regulates the activation of the nuclear factor of activated T-cells (NFAT) family of transcription factors, which are key regulators of T-cell development and function. Here, we generated a conditional Cnb1 mouse model in which Cnb1 was specifically del...