A trade-off between solubility enhancement and physical stability upon simultaneous amorphization and nanonization of curcumin in comparison to amorphization alone

• المؤلفون الرئيسيون: Wong, Jerome Jie Long, Yu, Hong, Lim, Li Ming, Hadinoto, Kunn
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Curcumin; Nanoparticles
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/87714; http://hdl.handle.net/10220/45493

The numerous health benefits of curcumin (CUR) have not been fully realized due to its low aqueous solubility, resulting in poor bioavailability. While amorphization of CUR via amorphous solid dispersion (ASD) represents a well-established CUR solubility enhancement strategy, simultaneous amorphizat...