Stromal cyclin D1 promotes heterotypic immune signaling and breast cancer growth

• Main Authors: Pestell, Timothy G., Jiao, Xuanmao, Kumar, Mukesh, Peck, Amy R., Prisco, Marco, Deng, Shengqiong, Li, Zhiping, Ertel, Adam, Casimiro, Mathew C., Ju, Xiaoming, Di Rocco, Agnese, Di Sante, Gabriele, Katiyar, Sanjay, Shupp, Alison, Lisanti, Michael P., Jain, Pooja, Wu, Kongming, Rui, Hallgeir, Hooper, Douglas C., Yu, Zuoren, Goldman, Aaron R., Speicher, David W., Laury-Kleintop, Lisa, Pestell, Richard G.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: OPN; Cyclin D1
• Online Access: https://hdl.handle.net/10356/87751; http://hdl.handle.net/10220/45547
• Institution: Nanyang Technological University

The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that drives cell autonomous cell cycle progression and proliferation. Herein we show cyclin D1 abundance is increased >30-fold in the stromal fibroblasts of patients with invasive breast cancer, associated with poor outcome. Cyclin...