Systematic evaluation of genes and genetic variants associated with type 1 diabetes susceptibility

• Main Authors: Boehm, Bernhard Otto, Morahan, Grant, Ram, Ramesh, Mehta, Munish, Nguyen, Quang T., Larma, Irma, Pociot, Flemming, Concannon, Patrick
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Diabetes; Genes and Genetic Variants; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/87809; http://hdl.handle.net/10220/46817
• Institution: Nanyang Technological University

Genome-wide association studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D). Many of these are defined only by anonymous single nucleotide polymorphisms: the underlying causative genes, as well as the molecular bases by which they mediate susceptibility, are no...