Utf1 contributes to intergenerational epigenetic inheritance of pluripotency

• Main Authors: Bao, Qiuye, Morshedi, Amir, Wang, Fulu, Bhargy, Sharma, Pervushin, Konstantin, Yu, Wei-Ping, Dröge, Peter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Primordial Germ Cells (PGCs); Pluripotency
• Online Access: https://hdl.handle.net/10356/87884; http://hdl.handle.net/10220/45565
• Institution: Nanyang Technological University

Undifferentiated embryonic cell transcription factor 1 (Utf1) is expressed in pluripotent embryonic stem cells (ESCs) and primordial germ cells (PGCs). Utf1 expression is directly controlled by pluripotency factors Oct4 and Sox2, which form a ternary complex with the Utf1 enhancer. The Utf1 protein...