Insights into Biofilm Dispersal Regulation from the Crystal Structure of the PAS-GGDEF-EAL Region of RbdA from Pseudomonas aeruginosa

• Main Authors: Liu, Chong, Liew, Chong Wai, Wong, Yee Hwa, Tan, Siok Thing, Poh, Wee Han, Manimekalai, Malathy S. S., Rajan, Sreekanth, Xin, Lingyi, Liang, Zhao-Xun, Grüber, Gerhard, Rice, Scott A., Lescar, Julien
• Other Authors: Metcalf, William W.
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cyclic Di-GMP; PAS Domain
• Online Access: https://hdl.handle.net/10356/88033; http://hdl.handle.net/10220/44542
• Institution: Nanyang Technological University

RbdA is a positive regulator of biofilm dispersal of Pseudomonas aeruginosa. Its cytoplasmic region (cRbdA) comprises an N-terminal Per-ARNT-Sim (PAS) domain followed by a diguanylate cyclase (GGDEF) domain and an EAL domain, whose phosphodiesterase activity is allosterically stimulated by GTP bindi...