Charged residues next to transmembrane regions revisited: “Positive-inside rule” is complemented by the “negative inside depletion/outside enrichment rule”

• المؤلفون الرئيسيون: Baker, James Alexander, Wong, Wing-Cheong, Eisenhaber, Birgit, Warwicker, Jim, Eisenhaber, Frank
• مؤلفون آخرون: School of Computer Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Amino Acid Distribution; Genome-wide Statistical Study
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88052; http://hdl.handle.net/10220/44533

Background: Transmembrane helices (TMHs) frequently occur amongst protein architectures as means for proteins to attach to or embed into biological membranes. Physical constraints such as the membrane’s hydrophobicity and electrostatic potential apply uniform requirements to TMHs and their flanking...