Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death

• Main Authors: Bernardinelli, Emanuele, Costa, Roberta, Scantamburlo, Giada, To, Janet, Morabito, Rossana, Nofziger, Charity, Doerrier, Carolina, Krumschnabel, Gerhard, Paulmichl, Markus, Dossena, Silvia
• Other Authors: Gallyas, Ferenc
• Format: Article
• Language: English
• Published: 2018
• Subjects: Mitochondrial Protein; Acyltransferase
• Online Access: https://hdl.handle.net/10356/88056; http://hdl.handle.net/10220/44530
• Institution: Nanyang Technological University

Lipoyl(Octanoyl) Transferase 2 (LIPT2) is a protein involved in the post-translational modification of key energy metabolism enzymes in humans. Defects of lipoic acid synthesis and transfer start to emerge as causes of fatal or severe early-onset disease. We show that the first 31 amino acids of the...