Alternative splicing analysis in human monocytes and macrophages reveals MBNL1 as major regulator

• Main Authors: Lorenzini, Paolo A., Wong, Mei Su M., Liu, Hongfei, Zhang, Fan, Xu, Shaohai, Zheng, Jie, Roca, Xavier
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Alternative Splicing; Human Monocytes
• Online Access: https://hdl.handle.net/10356/88100; http://hdl.handle.net/10220/45607
• Institution: Nanyang Technological University

We report the detailed transcriptomic profiles of human innate myeloid cells using RNA sequencing. Monocytes migrate from blood into infected or wounded tissue to differentiate into macrophages, and control inflammation via phagocytosis or cytokine secretion. We differentiated culture primary monocy...