Lybatides from Lycium barbarum contain an unusual cystine-stapled helical peptide scaffold

• Main Authors: Tan, Wei Liang, Wong, Ka Ho, Lei, Jian, Sakai, Naoki, Tan, Hong Wei, Hilgenfeld, Rolf, Tam, James P.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cysteine-rich Peptides; Lybatide; DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/88139; http://hdl.handle.net/10220/45616
• Institution: Nanyang Technological University

Cysteine-rich peptides (CRPs) of 2–6 kDa are generally thermally and proteolytically stable because of their multiple cross-bracing disulfide bonds. Here, we report the discovery and characterization of two novel cystine-stapled CRPs, designated lybatide 1 and 2 (lyba1 and lyba2), from the cortex of...