Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes

• Main Authors: van Krieken, Pim P., Dicker, Andrea, Eriksson, Maria, Herrera, Pedro L., Ahlgren, Ulf, Berggren, Per-Olof, Ilegems, Erwin
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Beta Cell; Diabetes; DRNTU::Science::Medicine
• 在線閱讀: https://hdl.handle.net/10356/88140; http://hdl.handle.net/10220/45614
• 機構: Nanyang Technological University

Functional beta cell mass is an essential biomarker for the diagnosis and staging of diabetes. It has however proven technically challenging to study this parameter during diabetes progression. Here we have detailed the kinetics of the rapid decline in functional beta cell mass in the RIP-DTR mouse,...