Kinetics of functional beta cell mass decay in a diphtheria toxin receptor mouse model of diabetes

• المؤلفون الرئيسيون: van Krieken, Pim P., Dicker, Andrea, Eriksson, Maria, Herrera, Pedro L., Ahlgren, Ulf, Berggren, Per-Olof, Ilegems, Erwin
• مؤلفون آخرون: Lee Kong Chian School of Medicine (LKCMedicine)
• التنسيق: مقال
• اللغة: English
• منشور في: 2018
• الموضوعات: Beta Cell; Diabetes; DRNTU::Science::Medicine
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/88140; http://hdl.handle.net/10220/45614

Functional beta cell mass is an essential biomarker for the diagnosis and staging of diabetes. It has however proven technically challenging to study this parameter during diabetes progression. Here we have detailed the kinetics of the rapid decline in functional beta cell mass in the RIP-DTR mouse,...