Calcium-dependent and synapsin-dependent pathways for the presynaptic actions of BDNF

• Main Authors: Cheng, Qing, Song, Sang-Ho, Augustine, George James
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2018
• Subjects: Neurotrophins; Synapsins; DRNTU::Science::Medicine
• Online Access: https://hdl.handle.net/10356/88507; http://hdl.handle.net/10220/45823
• Institution: Nanyang Technological University

We used cultured hippocampal neurons to determine the signaling pathways mediating brain-derived neurotrophic factor (BDNF) regulation of spontaneous glutamate and GABA release. BDNF treatment elevated calcium concentration in presynaptic terminals; this calcium signal reached a peak within 1 min an...