Proinflammatory cytokines induce endocrine differentiation in pancreatic ductal cells via STAT3-dependent NGN3 activation

• Main Authors: Valdez, Ivan Achel, Dirice, Ercument, Gupta, Manoj K., Shirakawa, Jun, Teo, Adrian Kee Keong, Kulkarni, Rohit N.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2018
• Subjects: DRNTU::Science::Biological sciences; Cytokines; Pancreatic Ducts
• Online Access: https://hdl.handle.net/10356/88611; http://hdl.handle.net/10220/46945
• Institution: Nanyang Technological University

A major goal of diabetes research is to develop strategies that replenish pancreatic insulin-producing beta cells. One emerging strategy is to harness pancreatic plasticity—the ability of pancreatic cells to undergo cellular interconversions—a phenomenon implicated in physiological stress and pancre...